Soil-transmitted helminth infections Infections and Infestations Helminthiasis, unspecified
Conditions
Interventions
Participants who were diagnosed with soil-transmitted helminths at the baseline parasitological examination will be randomly allocated to the following treatment arms:
Treatment arm 1: triple-dose alb
Sponsors
Swiss Tropical and Public Health Institute (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Primary school child, aged 9-12 years, male or female 2. Written informed consent by a parent / guardian on behalf of the child 3. Submission of two stool samples at baseline 4. Completion of anthropometric and haemoglobin measurements at baseline 5. Completion of 20 m shuttle run test at baseline 6. Completion of grip strength test and standing broad jump test at baseline 7. Infected with one or more common soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichuria, hookworm) 8. Absence of major systemic illnesses, as assessed by a medical doctor at baseline 9. No known or reported drug allergy to albendazole 10. Treatment with albendazole (or matching placebo) 11. Anticipated residence in the study area for at least 1 year
Exclusion criteria
Exclusion criteria: 1. Children below the age of 9 years or above 12 years 2. No written informed consent 3. Less than 2 stool samples submitted at baseline 4. Presence of medical condition that prevents child from completing the physical fitness and strength tests 5. Known or reported drug allergy to albendazole 6. Absence/refusal of albendazole treatment (or matching placebo) 7. Attending other clinical trials during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in physical fitness and strength | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reduction of infection prevalence and intensity of soil-transmitted helminths and subsequent re-infection pattern 2. Changes in anthropometric and haemoglobin measurements | — |
Countries
China
Outcome results
None listed