Acute Respiratory Failure requiring mechanical ventilation and endotracheal tube intubation Respiratory Acute respiratory failure
Conditions
Interventions
Inclusion:
1. Demographics
2. Duration of mechanical ventilation before inclusion
3. Pathology requiring intubation, history
4. Severity Score SAPS II and SOFA
5. Clinic: blood pressure, heart and res
Sponsors
Philips Respironics (France)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient ventilated on endotracheal tube for less than 7 days 2. Duration of mechanical ventilation predicted > 48h;Inclusion criteria: 1. Patient ventilated on endotracheal tube for less than 7 days 2. Duration of mechanical ventilation predicted > 48h
Exclusion criteria
Exclusion criteria: 1. Pre-existing neuromuscular pathology, suspected or proven 2. State of shock uncontrolled defined by the administration of norepinephrine or adrenaline at a dose> 0.3 mcg/kg/min 3. Moderate to severe acute respiratory distress syndrome (ARDS) defined by a PaO2/FiO2 ratio 0.3 mcg/kg/min 3. Moderate to severe acute respiratory distress syndrome (ARDS) defined by a PaO2/FiO2 ratio <200 mmHg 4. Undrained pneumothorax 5. Hemoptysis active or less than 15 days 6. Intracranial hypertension 7. Decision to limit or stop the treatment 8. Pregnancy 9. Unable to follow study related procedures as explained by the investigator 10. Minor patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of drainage procedures for tracheobronchial secretions necessary for 24h;The number of drainage procedures for tracheobronchial secretions necessary for 24h | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The volume of bronchial secretions collected daily 2. The incidence of ventilator-acquired pneumonia defined by the presence of two of the following three criteria: 2.1. Hyperthermia > 38.3 ° C controlled to 4 hours apart 2.2. Leukocytosis > 10 G / l 2.3. Sputum purulent And the following two criteria: 2.4. Microbiological documentation as defined in the study protocol 2.5. New X-ray image evaluated by the two-point increase Score Weinberg 26 3. The incidence of atelectasis (radiographic or endoscopic diagnosis) 4. The clinical safety of the technique assessed by a visual analogue rating scale in conscious patients 5. The failure of the test airway defined by the occurrence of: 5.1. Increased heart rate of more than 30/min 5.2. Increased respiratory rate of more than 10/min 5.3. Respiratory distress with clinical signs of struggle 5.4. Change in systolic blood pressure over 30 mmHg 5.5. Desaturation of more than 4% SpO2 5.6. Increased the capnia more than 5 mmHg 6. The failure of extubation is defined by the need for reintubation within 72 hours. Reintubation criteria as defined in the study protocol 6.1. Criterion immediate intubation: 6.1.1. Cardiac or respiratory arrest 6.1.2. Respiratory break with loss of consciousness or dying breath 6.1.3. Psychomotor agitation not controlled by sedation 6.1.4. Dimensions persistent 6.1.5. Inhalation massive 6.1.6. Heart rate 7.35 or PaCO2 > 45 mmHg 6.2.2. SpO2 50% 6.3.3. Respiratory rate > 35/min 6.3.4. Disorder consciousness, agitation or asterixis 6.3.5. Clinical signs of respiratory control or exhaustion: use accessory respiratory muscles or swinging thoracoabdominal 7. The duration of invasive mechanical ventilation 8. The length of stay in the ICU 9. The length of hospital stay 10. Mortality in the ICU 11. In-hospital mortality;1. The volume of bronchial secretions collected daily 2. The incidence of ventilator-acquired pneumonia defined by the presence of two of the following three criteria: 2.1. Hyperther | — |
Countries
France
Contacts
Public Contact; ;
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Outcome results
None listed