Corneal transplantation Injury, Occupational Diseases, Poisoning Failure and rejection of transplanted organs and tissues
Conditions
Interventions
Patients receive a corneal transplant from a donor matched for HLA class I antigens (not more than two HLA-A and/or HLA-B mismatches combined) with 0, 1 or 2 HLA class II (HLA-DR) mismatches. The leve
Sponsors
University of Bristol (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients of any age or sex tissue typed by polymerase chain reaction using sequence-specific primers (PCR-SSP) or PCR using sequence-specific oligonucleotides (PCR-SSO) with corneal disease requiring a corneal transplant and with the following conditions that increase the risk of cell-mediated rejection: 1. Previously failed corneal transplant 2. Vascularised cornea 3. Ocular inflammatory disease 4. Bullous keratopathy consequent to previous ocular surgery
Exclusion criteria
Exclusion criteria: Patients requiring corneal transplants where the risk of rejection is low (e.g., keratoconus and Fuchs' endothelial dystrophy) and where there are no known pre-operative risk factors for rejection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first rejection | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to graft failure | — |
Countries
United Kingdom
Outcome results
None listed