Does a combination containing morphine and dexamethasone reduce pain after knee replacement surgery?

Morphine and dexamethasone incorporated cocktail regimen efficiently reduced postoperative pain in patients undergoing primary total knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN25027558

Enrollment

250

Registered

2022-02-27

Start date

2018-09-04

Completion date

Unknown

Last updated

2022-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain in patients undergoing primary total knee arthroplasty Surgery

Interventions

This study enrolled 213 patients and randomly assigned them to one of three groups. The randomisation process was simple randomization. Group I: morphine (5 mg), dexamethasone (5 mg),

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 50–70 years who were scheduled for elective primary total knee arthroplasty (TKA) were assessed for eligibility. This study included all patients who had been diagnosed with knee osteoarthritis

Exclusion criteria

Exclusion criteria: History of knee replacement surgery, hepatic or renal dysfunction, or ischemic heart diseases

Design outcomes

Primary

Measure	Time frame
1. Pain-reducing efficacy measured using the visual analog scale (VAS) score in the first 4 days after TKA surgery 2. Active and passive range of movement (ROM) measured using a physical examination of the knee joint in the first 4 days after TKA surgery	—

Secondary

Measure	Time frame
1. Complications (wound leakage and superficial infection) and other adverse events (cardiac infarction, stroke, and acute renal failure) monitored using renal function tests including serum creatinine (Cr) and blood urea nitrogen (BUN), physical examination, and questioning the patients during hospitalization 2. Potential side effects, including headache, dizziness, nausea, and vomiting, monitored by questioning the patients during hospitalization	—

Measure

Time frame

1. Complications (wound leakage and superficial infection) and other adverse events (cardiac infarction, stroke, and acute renal failure) monitored using renal function tests including serum creatinine (Cr) and blood urea nitrogen (BUN), physical examination, and questioning the patients during hospitalization 2. Potential side effects, including headache, dizziness, nausea, and vomiting, monitored by questioning the patients during hospitalization

—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026