Auto-titrating continuous positive airway pressure in patients with chronic heart failure and obstructive sleep apnoea

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN24943566

Enrollment

Registered

2006-11-20

Start date

2002-07-01

Completion date

Unknown

Last updated

2022-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic heart failure and obstructive sleep apnoea Circulatory System Heart failure

Interventions

Auto-titrating CPAP versus sham CPAP.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Stable symptomatic CHF (Left Ventricular Ejection Fraction [LVEF] less than 45%) 2. On optimal medical therapy with obstructive sleep apnoea (Apnea-Hypopnea Index [AHI] more than or equal to 15)

Exclusion criteria

Exclusion criteria: 1. Acute coronary syndrome less than 3/12 2. Primary valvular heart disease 3. Sustained ventricular arrhythmias 4. Stroke with residual neurological deficit

Design outcomes

Primary

Measure	Time frame
Changes in peak maximal oxygen uptake (VO2) and six-minute walk distance.	—

Secondary

Measure	Time frame
Changes in: 1. LVEF 2. Minute ventilation versus carbon dioxide production (VE/VCO2) slope 3. Plasma neurohormonal makers 4. Quality of life	—

Countries

Scotland, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026