The PROHIBIT study: reducing patients' risk of developing a central venous catheter infection by improving catheter insertion and health care workers' hand hygiene compliance in European Intensive Care Units

The PROHIBIT (PRevention Of Hospital Infections By Intervention and Training ) intervention study: a randomized multi-centre study in Intensive Care Units in Europe to reduce central venous catheter-related bloodstream infections (CRBSIs) by improving hand hygiene (HH) and central venous catheter (CVC) insertion and care, measuring both CRBSI incidence density and HH and CVC insertion compliance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN24828982

Enrollment

15000

Registered

2015-09-15

Start date

2011-01-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter-related bloodstream infections Infections and Infestations Catheter-related bloodstream infections

Interventions

The cluster-randomized stepped wedge design allowed all centres to implement the intervention and to account for time-related changes. The baseline period functions as control period. Hospitals were r

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. ICU patients with CVCs in place for at least 24 hours 2. Aged 16 years or over

Exclusion criteria

Exclusion criteria: 1. CVCs inserted outside the hospital 2. CVCs removed at the same day

Design outcomes

Primary

Measure	Time frame
Central venous catheter-related bloodstream infection (CRBSI) incidence density, measured as number of CRBSI per 1000 CVC days (CVC days of concurrent CVCdays were counted separately) every 3 months for 30 months.	—

Secondary

Measure	Time frame
1. Hand hygiene complianceias measured by direct observation using the well-known WHO “My five moments for hand hygiene” strategy (Sax et al, AJIC 2009) every 3 months for 30 months 2. Catheter insertion practice is measured by observing CVC insertions using a form based on the CRBSI prevention strategy of the University of Geneva Hospitals (Zingg et al, PloS one, 2014) every 3 months for 30 months	—

Measure

Time frame

1. Hand hygiene complianceias measured by direct observation using the well-known WHO “My five moments for hand hygiene” strategy (Sax et al, AJIC 2009) every 3 months for 30 months 2. Catheter insertion practice is measured by observing CVC insertions using a form based on the CRBSI prevention strategy of the University of Geneva Hospitals (Zingg et al, PloS one, 2014) every 3 months for 30 months

—

Countries

Austria, Belgium, Belize, Greece, Hungary, Ireland, Italy, Latvia, Poland, Romania, Slovenia, Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026