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Pragmatic Cluster Randomised Controlled Trial of the Practical Approach to Lung Health and Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) in South Africa (PALSA PLUS) Educational Outreach Intervention

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN24820584
Enrollment
60
Registered
2006-02-10
Start date
2004-08-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS, Tuberculosis (TB), and STIs. Infections and Infestations HIV/AIDS, Tuberculosis (TB), and STIs.

Interventions

The trial is comparing educational outreach (based on guidelines) to passive dissemination of these guidelines to all nurses in control clinics combined with traditional off-site didactic training of

Sponsors

University of Cape Town Lung Institute (South Africa)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Clusters: primary care clinics participating in the first phases of the rollout of the national AntiRetroviral Treatment (ART) programme in the Free State province, South Africa Patients: All patients enrolled in the national ART programme at these clinics PALSA PLUS Western Cape trial: In addition to the above inclusion criteria, the PALSA PLUS Western Cape trial will also include primary care facilities where care for HIV and TB is provided. Patients: all patients 15 years or older attending these facilities for the trial duration (36 weeks).

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
1. TB case detection 2. Voluntary counselling and testing uptake 3. Cotrimoxazole prophylaxis provision

Secondary

MeasureTime frame
1. TB screening (sputum sampling) 2. Proportion of ART patients with undetectable viral loads at 6,12 and 18 months 3. Health-related quality of life 4. Hospitalisation 5. Mortality 6. Antiretroviral treatment interruptions

Countries

South Africa

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026