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A randomised controlled trial comparing spontaneous ureteric stone passage rates with tamsulosin versus placebo in the management of acute renal colic

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN24675122
Enrollment
206
Registered
2004-09-30
Start date
2008-05-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases: Acute renal colic Urological and Genital Diseases Acute renal colic

Interventions

As of 28/03/2013 the trial status was changed to 'stopped' as the trial was closed in January 2011 due to recruitment issues. Please note that, as of 11/04/2008, the anticipated start and end dates o

Sponsors

Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The total sample size required to produce statistically significant results is 206 patients (103 to receive placebo). All patients with renal colic with a visible calculus on X-ray which has been confirmed to be present within the ureter on intravenous urogram (IVU) will be asked to participate.

Exclusion criteria

Exclusion criteria: Patients will be excluded if pregnant, symptoms present for >14 days, evidence of infection or if they are already receiving treatment with tamsulosin or other calcium channel blocker.

Design outcomes

Primary

MeasureTime frame
Primary outcome measures amended as of 11/04/2008: 1. Spontaneous stone passage within 6 weeks 2. Early intervention due to complications Primary outcome measures provided at time of registration: 1. The percentage of calculi passed spontaneously within 6 weeks 2. The mean time to spontaneous passage 3. The mean use of analgesia in the form of diclofenac (recommended first line analgesic)

Secondary

MeasureTime frame
Added as of 11/04/2008: The following will be assessed at the end of the trial, i.e. time of stone passage or 6 weeks if stone not passed: 1. Percentage of calculi passed spontaneously within six weeks 2. Mean time to spontaneous passage 3. Mean use of analgesia in the form of diclofenac

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026