Inflammation/calcium and bone metabolism Nutritional, Metabolic, Endocrine Vitamin D deficiency
Conditions
Interventions
Informed consent will be requested from the next of kin (closest family member or legal guardian) before inclusion in the study. The family member or the patient can withdraw from the trial, at any ti
Sponsors
Catholic University Leuven (Katholieke Universiteit Leuven) (Belgium)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients admitted to any of the four intensive care units with an anticipated Intensive Care Unit (ICU) stay of greater than 10 days 2. Older than 18 years, either sex
Exclusion criteria
Exclusion criteria: 1. Younger than 18 years 2. Patients suffering from chronic bone disease 3. Patients suffering from parathyroid disease 4. Patients suffering from chronic kidney disease 5. Patients known to be pregnant or nursing 6. Prior treated with glucocorticoids before ICU admission 7. Patients with a 'do not resuscitate' (DNR) code at the time of ICU admission 8. Patients already enrolled in another trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Inflammation and innate immunity patterns, daily during study period (from day 0 till day 10) 2. Bone turnover and vitamin D status: via blood and urine analyses, daily during study period (from day 0 till day 10) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Infections, during ICU stay: from admission untill ICU discharge 2. Organ function: Apache (measured upon ICU admission) and Sequential Organ Failure Assessment (SOFA) (measured daily during study period [from day 0 till day 10]) scores 3. ICU stay, measured upon discharge 4. Mortality (ICU, hospital), measured during ICU stay and hospital stay | — |
Countries
Belgium
Outcome results
None listed