Obesity-related disease, non-insulin dependent diabetes mellitus Nutritional, Metabolic, Endocrine Non-insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention group: High n-3 cooking oil (rapeseed oil) plus fish oil derived EPA/DHA capsules (3 g daily)
Control group: High n-6 cooking oil (sunflower oil) plus placebo corn oil cap
Sponsors
Medical Research Council (MRC) (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female living in Bakau (urban area in the Gambia) 2. Aged 30 years or older 3. Being obese i.e. having a body mass index more than or equal to 27 kg/m^2 4. Having an impaired glucose tolerance (oral glucose tolerance test; 120-minute glucose between 6.7 and 10.0 mmol/l) 5. Subjects consent
Exclusion criteria
Exclusion criteria: Subjects diagnosed as diabetic by their doctor or on medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcomes were measured before baseline, at baseline, at three and six months of the intervention: 1. Full plasma and adipose tissue fatty acid analysis 2. Fasting glucose 3. Fasting insulin 4. Oral glucose tolerance test | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Anthropometric measurements (fat mass and fat free mass, waist-to-hip ratio) 2. Diastolic and systolic blood pressure 3. Full lipid profile 4. Plasma Tumour Necrosis Factor (TNF)alpha and receptors 5. Plasma InterLeukin-6 (IL-6) and receptors 6. Sialic acid | — |
Countries
Gambia
Outcome results
None listed