The effect of mindfulness based intervention in cognitive functions and psychological well-being applied as an early intervention in schizophrenia and high risk mental state

The effect of mindfulness based intervention in cognitive functions and psychological well-being applied as an early intervention in schizophrenia and high risk mental state: a randomized controlled trial protocol in a Chilean sample

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN24327446

Enrollment

Registered

2016-09-12

Start date

2016-10-01

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia and high risk mental state Mental and Behavioural Disorders Schizophrenia and high risk mental state

Interventions

Participants will be randomly allocated (a simple randomized sampling will be used) to the trial or control group by independent researchers using a stratified block randomization procedure with a com

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with a first episode of schizophrenia or in high-risk of psychosis, as applicable 2. Aged between 15 and 35 years 3. Clinical stability defined by medical and psychometric criteria (e.g. PAANS)

Exclusion criteria

Exclusion criteria: 1. Risk of suicide 2. Severe intellectual disability (mental retardation) 3. Medical illness inconsistent with the intervention 4. Substance abuse or dependence in the past six months

Design outcomes

Primary

Measure	Time frame
Cognitive function is assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) at baseline, 1 week and 3 months post-intervention	—

Secondary

Measure	Time frame
1. Psychological well-being is measured through the Ryff's Psychological Well-Being Scales (PWB) at baseline, 1 week and 3 months post-intervention 2. Self-esteem is measured through the Rosenberg Self-esteem Scale at baseline, 1 week and 3 months 3. Mindfulness is measured through the Five Facet Mindfulness Questionnaire (FFMQ) at baseline, 1 week and 3 months post-intervention 4. Affect is measured through the Positive and Negative Affect Schedule (PANAS) at baseline, 1 week and 3 months post-intervention 5. Worry is measured through the Penn State Worry Questionnaire (PSWQ-11) at baseline, 1 week and 3 months post-intervention 6. General symptomatology is measured through the Depression, Anxiety and Stress Scale (DASS-21) at baseline, 1 week and 3 months post-intervention 7. Subjective experience is measured through a semi structured interview at four weeks after completing the intervention	—

Measure

Time frame

1. Psychological well-being is measured through the Ryff's Psychological Well-Being Scales (PWB) at baseline, 1 week and 3 months post-intervention 2. Self-esteem is measured through the Rosenberg Self-esteem Scale at baseline, 1 week and 3 months 3. Mindfulness is measured through the Five Facet Mindfulness Questionnaire (FFMQ) at baseline, 1 week and 3 months post-intervention 4. Affect is measured through the Positive and Negative Affect Schedule (PANAS) at baseline, 1 week and 3 months post-intervention 5. Worry is measured through the Penn State Worry Questionnaire (PSWQ-11) at baseline, 1 week and 3 months post-intervention 6. General symptomatology is measured through the Depression, Anxiety and Stress Scale (DASS-21) at baseline, 1 week and 3 months post-intervention 7. Subjective experience is measured through a semi structured interview at four weeks after completing the intervention

—

Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026