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Comparing large chest drains with small chest drains to explore the best treatments for chest injury

Randomised trial of the clinical and cost effectiveness of small bore, Seldinger, versus large bore, surgical, chest drains for the treatment of traumatic haemo/pneumothoraces – (CoMiT-ED 2)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN24272044
Enrollment
1678
Registered
2026-02-17
Start date
2026-05-19
Completion date
Unknown
Last updated
2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine

Interventions

Trial design and setting This is a pragmatic multicentre, parallel-group, individually randomised, superiority trial with internal pilot, economic evaluation and integrated QRI. The trial will recrui

Sponsors

North Bristol NHS Trust
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 110 Years

Inclusion criteria

Inclusion criteria: Potential participants must satisfy the following criteria to be enrolled in this study: 1. Patients presenting to hospital with a traumatic pneumothorax, haemothorax or haemopneumothorax (unilateral or bilateral) confirmed on computed tomography (CT) up to 24 hours from presentation; 2. aged, or believed to be aged, 16 years and over 3. AND in whom the treating clinician(s) believes a chest drain is required.

Exclusion criteria

Exclusion criteria: Potential participants who meet any of the following criteria will be excluded from participation: 1. Treating clinician(s) believe injuries are immediately incompatible with life, whereby the patients have no ongoing active management of other injuries or palliation is being undertaken. 2. Patient in cardiorespiratory arrest at the point of randomisation. 3. Retrospective paediatric exclusion if patient confirmed to be less than 16 years.

Countries

England, Northern Ireland, United Kingdom, Wales

Contacts

Public ContactGraziella Mazza
comited2-trial@bristol.ac.uk+44 117 455 0644

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 22, 2026