Randomised prospective European Multicenter Oscillator Acute Respiratory Distress Syndrome (ARDS) Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN24242669

Enrollment

Registered

2005-05-12

Start date

1997-10-01

Completion date

Unknown

Last updated

2020-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome (ARDS) Respiratory Acute respiratory distress syndrome (ARDS)

Interventions

High frequency oscillatory ventilation (HFOV) compared with conventional mechanical ventilation (CMV).

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with ARDS, defined as: 1.1. The pressure of arterial oxygen divided by the fraction of inspired oxygen (paO2/FiO2) less than 200 mmHg 1.2. Radiographic evidence of bilateral infiltrates on chest X-ray 1.3. No evidence of atrial hypertension 2. Body weight greater than 35 kg

Exclusion criteria

Exclusion criteria: 1. Non-pulmonary terminal disease 2. Severe chronic obstructive pulmonary disease 3. Asthma and grade 3 or 4 air-leak 4. FiO2 greater than 0.80 for 48 hours 5. More than 10 days of mechanical ventilation

Design outcomes

Primary

Measure	Time frame
1. Cumulative survival without mechanical ventilation or oxygen dependency at 30 days 2. Mortality at 30 days	—

Secondary

Measure	Time frame
1. Therapy failure 2. Crossover rate 3. Persisting pulmonary problems defined as oxygen dependency or still being on a ventilator at 30 days	—

Countries

France, Germany, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026