Post-antibiotic vulvovaginitis Infections and Infestations Post-antibiotic vulvovaginitis
Conditions
Interventions
Factorial design to test oral and vaginal lactobacillus species.
Sponsors
University of Melbourne (Australia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women aged between 18 and 50 years of age 2. Who are experiencing a non-genital infection 3. Rrequiring a short-course of oral antibiotics or have commenced this within the 48 hours preceding enrolment 4. English-speaking: able to speak, read and write in English sufficiently to provide informed consent and complete surveys
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Experiencing any vaginal symptoms at recruitment 3. Unwilling or unable to provide two self-collected low vaginal swabs (at recruitment and on completion of trial) 4. Using or have used vaginal antifungal treatments in the past two weeks 5. Have taken antibiotics in the past month 6. Unwilling to stop taking other lactobacillus products during the trial 7. Immunocompromised, as there are rare reports in the literature of lactobacilli causing endocarditis and bacteraemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is symptomatic vulvovaginal candidiasis, defined as: 1. Participants' report of symptoms (that is answer 'yes' to a question about symptoms of 'thrush' in survey 2: vaginal itch, irritation with or without a discharge) 2. Swab B culture positive for Candida species | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Australia
Outcome results
None listed