Change in neck vein flow after chronic cerebro-spinal venous insufficiency (CCSVI) therapy in patients with multiple sclerosis

Pulsed short magnetic resonance imaging (MRI) to quantify neck vascular flow changes after jugular venous dilation (venoplasty) in patients with multiple sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN24087468

Enrollment

Registered

2011-06-10

Start date

2011-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multple sclerosis/ diagnostic imaging Nervous System Diseases Multiple sclerosis

Interventions

Observations: 1. MRI flow quantification will be used to measure blood flow rate averaged over 2 minutes within the right and left internal jugular veins 2. At the same level within the upper neck, le

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Above 19 years of age 2. Has been diagnosed with multiple sclerosis 3. Has an MRI of the neck veins with flow quantification prior to having jugular venoplasty (CCSVI treatment) within the past 1 year

Exclusion criteria

Exclusion criteria: 1. Patients who have a contraindication to MRI scan 2. Patients with metal implants such as: 2.1. In the eye 2.2. Non-MRI compatible stents 2.3. Staples

Design outcomes

Primary

Measure	Time frame
Paired t-test statistical analysis will be used to assess for significance	—

Secondary

Measure	Time frame
Questionnaire answers will be tabulated to assess for change	—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026