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A London HPV self-sampling pilot

Self-sampling for HPV testing in cervical screening nonattenders in London

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN23940319
Enrollment
3196
Registered
2018-07-25
Start date
2019-04-09
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical cancer Cancer Malignant neoplasms of female genital organs

Interventions

This will be a randomised controlled pilot study at ~12 GP practices in London within the Hounslow Clinical Commissioning Group (CCG). Each GP practice will recruit over a period of 12 months and will

Sponsors

Queen Mary University of London
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Women aged 25-64 years 2. Eligible for cervical screening 3. At least 6 months overdue (i.e. no cervical screening recorded in the GP records in the past 3.5 years if aged 25-49 or 5.5 years if aged 50-64)

Exclusion criteria

Exclusion criteria: Women unable to provide informed consent

Design outcomes

Primary

MeasureTime frame
This is a pilot study therefore there is no formal primary outcome measure. The study will calculate measures of feasibility and acceptability such as the proportion of eligible women who are offered kits, accept and return a self-sample following each intervention (i.e. (i) opportunistic offer of self-sampling kits, (ii) women invited to order a self-sampling kit, and (iii) women sent self sampling kit) at 6 months and 12 months after the invitation/offer of self sampling

Secondary

MeasureTime frame
1. The proportion of eligible women who test HPV positive and a) attend for follow up (cytology or colposcopy) within 6 months of testing HPV positive on a SS and b) who are treated for CIN2+ 2. “Coverage” of cervical screening following different interventions – when additionally counting an HPV negative test on self-sample as “screened” 3. Use of website in the intervention arm (women invited to order a kit)

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026