The roles of decreasing sedentary behaviors on artery health and overall quality of life in individuals with peripheral arterial disease

Effects of reducing sedentary behaviors on total wellness, vascular reactivity, and vascular stiffness in adults with peripheral arterial disease: a 12-week randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN23904851

Enrollment

Registered

2018-01-29

Start date

2015-05-01

Completion date

Unknown

Last updated

2018-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral arterial disease Circulatory System Peripheral vascular disease, unspecified

Interventions

Subjects randomized to two groups using standardized procedures employing an online random number generator: 1. Control group: (attention control): subjects received six 10-minute videos on various as

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 50 years or older 2. Ankle Brachial Index of 0.90 or lower 3. Non-sleep daily sedentary time of 8 or more hours 4. Able to access and utilize a home personal computer

Exclusion criteria

Exclusion criteria: 1. Unable to obtain an ABI 2. Lower limb amputation 3. Inability to ambulate 25 feet independently 4. Current foot ulceration 5. Presence of myocardial ischemia or NY Heart Association Class II heart failure 6. Uncontrolled hypertension 7. Uncontrolled diabetes 8. Undergone lower limb re-vascularization procedures

Design outcomes

Primary

Measure	Time frame
1. EndoPAT measurements at baseline and immediately following the conclusion of the 12-week intervention. EndoPat is a non-invasive instrument used to measure endothelial function and vascular compliance. EndoPAT quantifies the endothelium-mediated changes in vascular tone, produced by a 5-minute occlusion of the brachial artery (using a standard blood pressure cuff). When the cuff is released, the surge of blood flow causes an endothelium-dependent flow mediated dilatation. The dilatation, manifested as Reactive Hyperemia, is captured by EndoPAT as an increase in the PAT Signal amplitude. A post-occlusion to pre-occlusion ratio is auto calculated by the EndoPAT software, providing the EndoPAT index. 2. ActivPAL measurements for 7 continuous days at baseline and following the 12-week study intervention. ActivPAL is a thigh worn accelerometer that provides quantification of free-living sedentary, upright and ambulatory activities	—

Measure

Time frame

1. EndoPAT measurements at baseline and immediately following the conclusion of the 12-week intervention. EndoPat is a non-invasive instrument used to measure endothelial function and vascular compliance. EndoPAT quantifies the endothelium-mediated changes in vascular tone, produced by a 5-minute occlusion of the brachial artery (using a standard blood pressure cuff). When the cuff is released, the surge of blood flow causes an endothelium-dependent flow mediated dilatation. The dilatation, manifested as Reactive Hyperemia, is captured by EndoPAT as an increase in the PAT Signal amplitude. A post-occlusion to pre-occlusion ratio is auto calculated by the EndoPAT software, providing the EndoPAT index. 2. ActivPAL measurements for 7 continuous days at baseline and following the 12-week study intervention. ActivPAL is a thigh worn accelerometer that provides quantification of free-living sedentary, upright and ambulatory activities

—

Secondary

Measure	Time frame
Wellness Evaluation of Lifestyle (WEL) survey instrument (paper and pencil version with 123 self-scored statements in which the subject replies to each statement using a five-point Likert scale) taken at baseline and following the 12-week intervention	—

Countries

United States of America

Contacts

Public ContactSteve Laslovich

slaslovich@usa.edu+1 (0)760 994 3576

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026