Congenital Heart Disease (CHD) Circulatory System Other congenital malformations of heart
Conditions
Interventions
We planned an intra-individual study, where 20 adult patients with CHD (e.g. Fallot Tetralogy, s/p corrective surgery, single ventricle s/p Fontan operation, aortic and pulmonary artery stenosis) will
Sponsors
Guy's Hospital (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The main inclusion criteria will be patient with CHD, i.e. complex congenital defects such as: 1. Aortic abnormalities 2. Pulmonary artery abnormalities 3. Systemic or pulmonary venous abnormalities 4. The study will be limited to patients aged 18 and over
Exclusion criteria
Exclusion criteria: The study will involve MR contrast agents and and MRI scans, therefore the principle exclusion criteria are: 1. Any contra-indications to MR (e.g. pacemakers) 2. Known allergy to MR contrast agents 3. Patients not agreeing to take part in study 4. Pregnancy and nursing mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The improvement of diagnosis of CHD, due to larger coverage of vascular territories, higher spatial resolution, faster acquisition and higher quality of MR-flow measurements using Vasovist in comparison with standard Gd-agent 2. The improvement of image quality will be analysed by measuring the SNR, the CNR, the vessel sharpness. In addition, the overall image quality will be scored by three independent readers (scale: excellent, good, ok, bad) 3. Ventricular volumes measured from the acquired data will be compared with respect to a reference 4. The accuracy (standard deviation) and reproducibility of the flow measurements will be compared using the two different agents | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
United Kingdom
Outcome results
None listed