Chronic cough Respiratory Chronic cough
Conditions
Interventions
96 chronic cough patients and 96 healthy volunteers are recruited to this study.
In attempt to establish normal reference ranges, the healthy volunteers will be evenly recruited by ag
Sponsors
University Hospital of South Manchester NHS Foundation Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers: 1. Male and female aged over 18 years 2. Normal spirometry 3. No current or past history of chronic cough or respiratory disease 4. No current chronic pain, irritable bowel syndrome, psychiatric illness or chronic headaches Chronic cough patients: 1. Male and female aged over 18 years 2. Diagnosis of chronic cough (defined as cough lasting more than 8 weeks) 3. Normal spirometry 4. Normal chest x-ray
Exclusion criteria
Exclusion criteria: 1. Current smoker or ex-smoker with >20 pack year history, and >6 months abstinence 2. Upper respiratory tract infection within last 4 weeks 3. Use of angiotensin-converting-enzyme (ACE) inhibitors 4. Use of any centrally acting medications which may alter the cough reflex* 5. History of drug or alcohol abuse 6. Pregnancy or breastfeeding 7. Concomitant conditions which may alter cough reflex sensitivity e.g. diabetes mellitus, Parkinson?s disease, cerebrovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emax (maximum number of coughs provoked) and ED50 (capsaicin dose provoking half the Emax) will be measured to discriminate between male and female chronic cough patients and healthy controls to test the usefulness of the procedure as a clinical test. Measured at baseline only. | — |
Secondary
| Measure | Time frame |
|---|---|
| Emax, ED50, cough severity visual analogue scales (VAS) and objective cough frequency will also be used to assess differences in male and female healthy volunteers and chronic cough patients. Measured at baseline only. | — |
Countries
England, United Kingdom
Outcome results
None listed