Postoperative hypoparathyroidism (disorder of parathyroid function) following thyroidectomy Nutritional, Metabolic, Endocrine Postprocedural hypoparathyroidism
Conditions
Interventions
Participants are randomized to one of the following two groups:
1. Non-bilateral truncal ligation of the inferior thyroid artery during subtotal thyroidectomy (control group)
Sponsors
SRH Wald-Klinikum Gera (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients (18?80 years) with a multinodular non-toxic goitre 2. Normal serum albumin, total calcium and serum parathormone (PTH) 3. Normal vocal cord mobility
Exclusion criteria
Exclusion criteria: 1. Thyroid volume >150 ml 2. Toxic goitre (including Grave's disease) 3. Patients admitted for either unilateral resection or resection of recurrent goitre 4. Parathyroid dysfunction 5. Renal insufficiency 6. Haematopoietic disorders 7. Abnormal calcium metabolism 8. Prior radioiodine therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of clinically manifest hypoparathyroidism. Patients are asked about symptoms daily, in the morning and afternoon (i.e., paraesthesia in the face or hands, tingling periorally or in the fingers), and patients are clinically tested for Chvostek's and Trousseau's signs. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative asymptomatic hypocalcaemia and hypoparathyroidism, measured one day before the operation, intraoperatively at skin closure, and on postoperative days 2 and 5 during hospital stay. | — |
Countries
Germany
Outcome results
None listed