Can a rapid screening strategy improve infection control in critically ill patients?

A quasi-experimental interventional study to evaluate the impact of a rapid screening strategy in improving nosocomial ESBL and CPE control in critically ill patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN23588440

Enrollment

101

Registered

2019-03-11

Start date

2019-04-01

Completion date

Unknown

Last updated

2022-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection by ESBL or CPE bacteria Infections and Infestations

Interventions

This quasi-experimental study will alternate two 12-months intervention and control periods, and a 2-months wash-out period in-between. During the intervention period, a novel ESBL/CPE screening strat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients admitted to the Intensive Care Units during the study period

Exclusion criteria

Exclusion criteria: N/A

Design outcomes

Primary

Measure	Time frame
Unnecessary pre-emptive isolation-days will be determined using Turn-Around-Times for ESBL/CPE screening and work up, with the help of computerized laboratory databases and a specific tool integrated into the electronic patient file, informed in real time by patient dedicated nurses. This outcome will be measured for all high-risk patient with a negative result for ESBL and CPE on a targeted screening at admission, at the time of discontinuation of pre-emptive isolation.	—

Measure

Time frame

Unnecessary pre-emptive isolation-days will be determined using Turn-Around-Times for ESBL/CPE screening and work up, with the help of computerized laboratory databases and a specific tool integrated into the electronic patient file, informed in real time by patient dedicated nurses. This outcome will be measured for all high-risk patient with a negative result for ESBL and CPE on a targeted screening at admission, at the time of discontinuation of pre-emptive isolation.

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Secondary

Measure	Time frame
1. Time between patient screening and implementation of contact precaution of previously unknown ESBL-PE and CPE carriers will be determined using Turn-Around-Times for ESBL/CPE screening and work up, with the help of computerized laboratory databases and a specific tool integrated into the electronic patient file, informed in real time by patient dedicated nurses. This outcome will be measured for all patients newly positive for ESBL and CPE on a weekly screening, at the time of implementation of contact precaution. 2. Adjusted incidence-density ratio of nosocomial ESBL/CPE acquisition will be determined using surveillance data prospectively collected by infection control nurses. This outcome will be measured monthly.	—

Measure

Time frame

1. Time between patient screening and implementation of contact precaution of previously unknown ESBL-PE and CPE carriers will be determined using Turn-Around-Times for ESBL/CPE screening and work up, with the help of computerized laboratory databases and a specific tool integrated into the electronic patient file, informed in real time by patient dedicated nurses. This outcome will be measured for all patients newly positive for ESBL and CPE on a weekly screening, at the time of implementation of contact precaution. 2. Adjusted incidence-density ratio of nosocomial ESBL/CPE acquisition will be determined using surveillance data prospectively collected by infection control nurses. This outcome will be measured monthly.

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Countries

Switzerland

Contacts

Public ContactStephan Harbarth

stephan.harbarth@hcuge.ch+41 (0)22 372 98 28

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026