Female infertility Pregnancy and Childbirth Infertility
Conditions
Interventions
Randomised controlled trial of folic acid (400 mcg) versus Pregnacare Plus (contains folic acid 400 mcg and 17 other micronutrients) given for 10 weeks prior to assisted conception and follow-up to 20
Sponsors
The Royal Surrey County Hospital NHS Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Sub-fertile subjects scheduled for In Vitro Fertilisation (IVF) or Intra-Uterine Insemination (IUI) 2. Aged less than 35 years 3. Infertility lasting for greater than six months
Exclusion criteria
Exclusion criteria: 1. Aged greater than 35 years 2. General medical conditions that make a patient unsuitable for assisted conception (i.e. morbid obesity) 3. Women whose understanding of English is insufficient to consent to participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival of assisted conception pregnancy to 20 weeks, or failure to conceive and failure of pregnancy to survive to 20 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of pregnancy 2. Birth weight (expressed as percentile birth weight in relation to length of pregnancy) 3. Abdominal circumference 4. Head circumference | — |
Countries
United Kingdom
Outcome results
None listed