Positron emission tomography (PET) measurement of the displaceability of [11C]FLB 457 from extra-striatal dopamine D2 receptors in man

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN23418225

Enrollment

Registered

2004-09-30

Start date

2001-09-02

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Not Applicable: Metabolism Not Applicable

Interventions

Double-blind, placebo controlled, randomised study to measure binding of [11C]FLB 457 after the administration of methylphenidate and placebo in normal volunteers.

Eligibility

Inclusion criteria

Inclusion criteria: Volunteers: 16. Males 25-65 yrs, females 45-65 yrs.

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
To measure accurately extra-striatal dopamine D2 receptor density in man. If [11C]FLB 457 is displaceable from extrastriatal D2 receptors, it will have great potential value for the measurement of extrastriatal dopamine levels.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026