Chronic kidney disease Urological and Genital Diseases Chronic kidney disease
Conditions
Interventions
Study design: Multi-centre prospective observational cohort with blood sample collection and transvaginal ultrasound.
Setting: specialist renal clinics in the UK
Stud
Sponsors
King's College Hospital NHS Foundation Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Study group: 1. Women with CKD Stages 1-5 including those with renal transplants and on dialysis 2. =18 years old but =49 years old 3. Willing and able to provide written informed consent Control group: 1. Women aged 18-49 years 2. Male factor infertility 3. Willing and able to provide written informed consent
Exclusion criteria
Exclusion criteria: Study group: 1. Pregnant patients or those who are currently breastfeeding 2. Patient who have active or previous disease/treatment which could have affected their ovarian reserve i.e. chemotherapy, radiotherapy, ovarian surgery 3. Patients who require a translator Control group: 1. Patients who have active or previous disease/treatment which could have affected their fertility 2. Patients who have female factor infertility, i.e. tubal factor, anovulatory disorders, endometriosis, fibroids, low ovarian reserve 3. Patients who have a known medical condition 4. Patient who require a translator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Fertility assessed using blood markers (AMH, oestradiol, FSH, LH, progesterone, testosterone) and transvaginal ultrasound scan at baseline, 3 months and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The relationship of infertility, chronic kidney disease and chronic inflammation investigated using blood markers (O-link inflammatory panel) at baseline, 3 months and 6 months 2. Quality of life measured by a qualitative survey at baseline | — |
Countries
England, United Kingdom
Outcome results
None listed