Renal cell carcinoma with inferior vena cava thrombus involvement Cancer
Conditions
Interventions
IR1-CAVALThromb is a prospective, multicenter, registry study. The researchers plan to invite several centers to the register. They will collect data on patients who undergo radical nephrectomy with c
Sponsors
Imperial College Healthcare NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Any person over the age of 18 years referred to a supra-regional MDT following a new diagnosis of suspected caval thrombus involved renal cancer
Exclusion criteria
Exclusion criteria: 1. Age under 18 years old 2. Patients who are found to have no evidence of caval thrombus on dedicated tertiary imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standard operating procedure (SOP) for radical nephrectomy and caval thrombectomy surgery generated using the RAND/University of California at Los Angeles (UCLA) appropriateness method, completed once the last patient recruited has reached 3-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Morbidity of patients undergoing surgery and those who do not undergo immediate operative management assessed using the Clavien-Dindo Classification and/or the common terminology criteria for adverse events (CTCAEv5.0) at 3-month follow-up 2. Patient-reported outcome measures and health-reported quality-of-life measured using: 2.1. Clinical frailty score at baseline and 3-month follow-up 2.2. EORTC QLQ-F17 and EQ-5D-5L validated questionnaire at baseline and 3-month follow-up 3. Surgical complications assessed using the Clavien-Dindo Classification of patients at 3 months follow-up 4. Key recommendations for optimal patient care and objectives for further research developed using the RAND/University of California at Los Angeles (UCLA) appropriateness method, completed once the last patient recruited has reached 3-month follow-up | — |
Countries
England, United Kingdom
Contacts
Public ContactMartin J. Connor
Outcome results
None listed