Persecutory delusions in the context of schizophrenia or related diagnosis Mental and Behavioural Disorders Schizophrenia or related diagnosis
Conditions
Interventions
1. Six sessions of CBT for worry over 2 months for patients randomised to intervention arm 2. This is in addition to their standard psychiatric care
3. The control condition is standard psychiatric ca
Sponsors
The Efficacy and Mechanism Evaluation Programme (MRC/NIHR) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. A current persecutory delusion as defined by Freeman and Garety (2000); scoring at least 3 on the conviction scale of the PSYRATS (Haddock et al, 1999) 2. That the delusion has persisted for at least one month 3. A clinical diagnosis of schizophrenia, schizoaffective disorder or delusional disorder (i.e. diagnosis of non-affective psychosis (F2) in the International Classification of Diseases and Diagnostic and Statistical Manual IV) 4. A clinically significant level of worry, as indicated by scores above 44 on the Penn State Worry Questionnaire (see Startup and Erickson, 2006) 5. Aged between 18 and 65 6. Where major changes in medication are being made, entry to the study would not occur until at least a month after stabilisation of dosage
Exclusion criteria
Exclusion criteria: 1. A primary diagnosis of alcohol or substance dependency 2. Organic syndrome or learning disability 3. A command of spoken English inadequate for engaging in therapy 4. Currently having individual cognitive behavioural therapy (CBT) (though previous CBT experience is not an exclusion)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Penn State Worry Questionnaire (PSWQ; Meyer et al, 1990) 2. Psychotic Symptoms Rating Scale - Delusions (PSYRATS; Haddock et al, 1999) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Paranoid Thoughts Scale (Green et al, 2008) 2. Positive and Negative Symptom Scale (PANSS; Kay, 1991). 3. EQ-5D (Brooks et al, 2003) | — |
Countries
United Kingdom
Outcome results
None listed