Critical care patients admitted with sepsis Infections and Infestations Sepsis, unspecified
Conditions
Interventions
Current interventions as of 21/10/2024:
Participant hearts will be examined using standard transthoracic echocardiogram (TTE) on 1 and 3 days of admission to ICU. From these images, the study team wil
Sponsors
Surrey and Sussex Healthcare NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged =18 years 2. Admission diagnosis of sepsis 3. Standard of care echocardiogram within 24 h of admission to ICU 4. Adequate echocardiography image quality that permits cardiac work analysis and/or strain assessment of the right ventricle free wall 5. Able to speak, understand and communicate in English 6. Written or verbal informed consent from the patient or next of kin
Exclusion criteria
Exclusion criteria: 1. Atrial fibrillation 2. Previous cardiac surgery 3. Pregnancy 4. Severe valvular disease 5. Inadequate echocardiography image quality
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 21/10/2024: Prediction of mortality at 30 days using myocardial work (MW) and right ventricle free wall strain (RVFWS) measured using transthoracic echocardiography on 1 and 3 days of ICU admission Previous primary outcome measures: 1. Prediction of mortality at 30 days using myocardial work (MW), Global Longitudinal Strain (GLS), and right ventricle free wall strain (RVFWS) measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission 2. Determining the clinically relevant level of correlation between mortality at 30 days and changes in MW, Global longitudinal strain (GLS) and RVFWS measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission and participant records between baseline and hospital discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| Previous secondary outcome measures as of 21/10/2024: 1. Association between MW, RVFWS with global longitudinal strain (GLS) and left ventricle ejection fraction (LVEF) measured using a non-parametric bootstrapping method on day 1 and day 3 2. Assess if any differences exist between male and female patients in MRW and RVFWS measured using permutation tests on admission (day 1) Previous secondary outcome measure: 1. Association between changes in MW, GLS, and RVFWS and length of stay in ICU measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission and participant records between baseline and hospital discharge 2. Association between changes in MW, GLS, and RVFWS to days on mechanical ventilation (if part of patient’s clinical management) measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission and participant records between baseline and hospital discharge 3. Prediction of mortality at 90 days predicted from measurements of MW, Global Longitudinal Strain (GLS), and right ventricle free wall strain (RVFWS) measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission 4. Changes in MW, RVFWS, and GLS measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission 5. Feasibility of obtaining suitable images measured using transthoracic echocardiogram at 1, 3, and 90 days of ICU admission | — |
Countries
England, United Kingdom
Contacts
Public ContactTheophilus Samuels
Outcome results
None listed