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Thyroid dysfunction in the elderly: quantifying the association between sub-clinical disease and (i) atrial fibrillation (and thus stroke) (ii) depression and (iii) cognitive dysfunction. A community based survey and clinical trial of thyroxine therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN23090699
Enrollment
Unknown
Registered
2002-09-12
Start date
2005-01-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid dysfunction Nutritional, Metabolic, Endocrine Disorders of thyroid gland

Interventions

Intervention: Thyroxine replacement therapy. Dose to be increased by 25 mcg steps during 6 monthly period of monthly monitoring of thyroid function Control: As for intervention group but placebo

Sponsors

The Health Foundation (UK)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Phase 1: Aged 65+ Phase 2a: Patients identified in Phase 1 to be suffering from sub-clinical hyperthyroidism Phase 2b: Patients identified in Phase 1 to be suffering from sub-clinical hypothyroidism

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

MeasureTime frame
Not provided at time of registration—

Secondary

MeasureTime frame
Not provided at time of registration—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026