Lean and obese individuals Nutritional, Metabolic, Endocrine Lean and obese individuals
Conditions
Interventions
Following provision of informed consent and study screening, eligible participants are given weighing scales and a standardisation booklet in order to fulfil standardisation requirements. This require
Sponsors
Oxford Brookes University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years 2. BMI of 18.5-25.0 kg/m2 or 30.0-40.0 kg/m2
Exclusion criteria
Exclusion criteria: 1. Allergic/intolerant to any of the foods provided in the study 2. Taking medication which could affect appetite 3. Smokers 4. A ‘restrained eater’, as defined by the TFEQ and DEBQ 5. Currently dieting to lose weight 6. Anaemic 7. Vegan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Energy intake assessed by the ad libitum buffet lunch that participants consume at the end of each trial in isolated booths at 180-195 mins (until participants reach satiety) 2. Visual Analogue Scales will be used to measure subjective sensations of appetite: Hunger, Fullness, Desire to Eat, Prospective Food Consumption and Nausea at 0 mins, 30 mins, 60 mins, 90 mins 120 mins and 180 mins 3. Gastric emptying, measured through the 13C octanoic acid breath test at 0 mins, 15 mins, 30 mins, 45 mins, 60 mins, 75 mins, 90 mins, 105 mins, 120 mins, 135 mins, 150 mins, 165 mins and 180 mins 4. Blood parameters implicated in fat-related appetite control: cholecystokinin, acylated ghrelin, PYY and ß-hydroxybutyrate. Blood samples taken at 0 mins, 30 mins, 60 mins, 90 mins 120 mins and 180 mins | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. 48 hour energy intake, through recorded diet diaries completed after the morning in the laboratory and the following day 2. Hedonic properties of the lipid (to outline palatability issues with the breakfasts which may confound the results) assessed by Qualitative Descriptive Analysis at 5 min | — |
Countries
United Kingdom
Outcome results
None listed