Rationale and design of the TRANSNephro study examining transition of post-kidney transplant adolescents

Rationale and design of the TRANSNephro study examining transition of post-kidney transplant adolescents: an analysis of present patient-centered care and multicenter randomized prospective open trial to test a new transition model using case-management and smartphone apps

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN22988897

Enrollment

100

Registered

2014-04-25

Start date

2014-05-01

Completion date

Unknown

Last updated

2025-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney transplantation Urological and Genital Diseases

Interventions

In phase I of the study, we are evaluating the patient transition situation in German nephrology departments, including an evaluation of the present situation in the view of physicians, nurses, and ps

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 16-21 years 2. Kidney transplantation in history

Exclusion criteria

Exclusion criteria: Patients severely mentally retarded

Design outcomes

Primary

Measure	Time frame
Variation coefficients for immunosuppressive agent levels, measured at the end of the study (1 year after transition)	—

Secondary

Measure	Time frame
1. Change in pre- and post-transfer estimated glomerular filtration rate (eGFR) (using the Schwartz 2009 formula, modification of diet in renal disease formula, and correction for cystatin-C levels) 2. Serum creatinine levels 3. Transplant survival 4. Patient survival 5. Acute rejection reactions (presence of donor-specific antibodies and chronic humoral rejection) 6. Transplant loss 7. Death 8. Patient satisfaction 9. Health care utilization 10. Patients? self-reported quality of life and social integration All outcomes will be measured at the end of the study (1 year after transition).	—

Measure

Time frame

1. Change in pre- and post-transfer estimated glomerular filtration rate (eGFR) (using the Schwartz 2009 formula, modification of diet in renal disease formula, and correction for cystatin-C levels) 2. Serum creatinine levels 3. Transplant survival 4. Patient survival 5. Acute rejection reactions (presence of donor-specific antibodies and chronic humoral rejection) 6. Transplant loss 7. Death 8. Patient satisfaction 9. Health care utilization 10. Patients? self-reported quality of life and social integration All outcomes will be measured at the end of the study (1 year after transition).

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 7, 2026