Residual treatment-resistant depression Mental and Behavioural Disorders
Conditions
Interventions
Intervention: Rumination-focused cognitive-behavioural therapy (RFCBT) as ajdunct to treatment-as-usual. RFCBT is a manualised CBT treatment, consisting of up to 12 individual 60 minute sessions sched
Sponsors
University of Exeter (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >18 2. Meeting criteria for medication-refractory residual depression defined as: 2.1. Meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for major depression within the last 18 months but not in the last 2 months 2.2. Residual symptoms reaching at least 8 on the 17-item Hamilton Depression Rating Scale (HRSD) and 9 on the Beck Depression Inventory (BDI-II) 2.3. Taking antidepressant medication at a therapeutic dose as recommended by the British National Formulary and/or equivalent to 125mg of amitriptyline for at least 8 weeks continuously during the current episode and within the last 2 months
Exclusion criteria
Exclusion criteria: 1. A history of bipolar disorder, psychosis 2. Current drug or alcohol dependence 3. Learning disability 4. Organic brain damage 5. Concurrent psychotherapy at point of entry to the study There were no exclusion criteria with respect to co-morbid anxiety disorders or Axis II diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Hamilton Rating Scale for Depression (HRSD) 2. Beck Depression Inventory (BDI-II) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The Structured Clinical Interview for DSM-IV (SCID) to assess diagnostic status for major depression 2. Ruminative Response Scale of the Response Styles Questionnaire (RRS) to assess rumination | — |
Countries
United Kingdom
Outcome results
None listed