Ischaemic heart disease Circulatory System Ischaemic heart disease
Conditions
Interventions
Patients with triple vessel coronary artery disease with or without associated significant disease of the left main stem and undergoing elective CABG surgery will be recruited for the study. Patients
Sponsors
University Hospitals of Leicester NHS Trust (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Triple vessel coronary artery disease with or without significant disease of the left main stem with indication of elective surgical revascularisation 2. Left ventricular ejection fraction greater than 40% 3. Age 20 to 80 years
Exclusion criteria
Exclusion criteria: In addition to not being compliant to the inclusion criteria, the following criteria will be sufficient to exclude patients from entering the study: 1. Cardiogenic shock (need for inotropic drugs, intra-aortic balloon pump) 2. Previous Coronary Artery Bypass Graft (CABG) 3. Percutaneous Coronary Infusion (PCI) in the previous three months 4. History of neoplastic disease 5. History of bleeding disorder 6. Chronic inflammatory disease 7. Active infection 8. Renal impairment (creatinine more than 180 mmol/l) 9. Liver dysfunction (Glutamate Oxalate Transferase [GOT] more than 2 x Upper Limit of Normal [ULN] or International Normalised Ratio [INR] more than 1.5 x ULN) 10. Diabetes 11. Chronic treatment with oral antibiotic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponin I in plasma | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Left ventricular function 2. Composite clinical outcome | — |
Countries
United Kingdom
Outcome results
None listed