Cystic fibrosis Nutritional, Metabolic, Endocrine Cystic fibrosis
Conditions
Interventions
1. Glutamine 21 g/day
2. Placebo
Treatment will continue for eight weeks for both. Follow up will occur for this entire period and a telephone call will be made 4 weeks later.
Sponsors
University of Nottingham (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Over 14 years old, male and female 2. Forced expiratory volume in one second (FEV1) greater than 40% predicted or receive regular nebulised saline treatment 3. Colonisation with Pseudomonas
Exclusion criteria
Exclusion criteria: 1. Current pregnancy or breastfeeding 2. Recent pulmonary exacerbation in past month 3. Lung transplant 4. Recently diagnosed or uncontrolled diabetes 5. Cirrhosis or severe liver failure 6. Initiation of new pulmonary therapies in the past month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in inflammatory markers in induced sputum, measured at baseline and after eight weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. FEV1 2. Serum C-reactive protein (CRP) 3. Infectious load of Pseudomonas 4. Systemic blood neutrophil activity 5. Jensen clinical score All outcomes measured at baseline and after eight weeks. | — |
Countries
United Kingdom
Outcome results
None listed