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How to judge for fluids in collapsed patients with severe infection

Dynamic testing based versus restrictive based fluid administration following early fluid resuscitation in septic shock patients: a pilot study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN22435678
Enrollment
80
Registered
2021-11-30
Start date
2019-11-01
Completion date
Unknown
Last updated
2021-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock Signs and Symptoms Septic shock

Interventions

This is a prospective cohort study, recruiting septic shock patients, conducted in the Critical Care Department, Cairo University. All patients are initially resuscitated. Patients are assigned accord

Sponsors

Cairo University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients =18 years old 2. Diagnosed with septic shock (sepsis with persisting hypotension despite adequate volume resuscitation and/or having a serum lactate level >4 mmol/l (18 mg/dl) requiring vasopressors to maintain mean arterial pressure =65 mmHg)

Exclusion criteria

Exclusion criteria: 1. Patients aged under 18 years 2. Refusal to consent 3. Conditions that could affect lactate clearance e.g., hepatic, or renal impairment 4. Alcoholic patients

Design outcomes

Primary

MeasureTime frame
Mortality measured through documenting mortality cases daily during the whole ICU stay

Secondary

MeasureTime frame
Measured during the whole ICU stay: 1. ICU length of stay measured through reviewing patient notes 2. Need for renal replacement therapy recorded on a daily basis through daily endorsement sheets and nursing documentation 3. Need for respiratory support recorded on a daily basis through daily endorsement sheets and nursing documentation 4. Need for vasopressors recorded on a daily basis through daily endorsement sheets and nursing documentation

Countries

Egypt

Contacts

Public ContactWalid Ahmed
walidkamel@cu.edu.eg+20 (0)1111632486

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026