Severe community-acquired pneumonia Respiratory Pneumonia
Conditions
Interventions
All patients received intravenous antibiotic treatment consisting of 1 g per day of ceftriaxone and 500 mg/day of levofloxacin. In addition, a bolus of 200 mg of MPDN or placebo was administered, 30 m
Sponsors
Institute of Health Carlos III (Instituto de Salud Carlos III) (Spain)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Community-acquired pneumonia (CAP) presenting extensive radiographic consolidations (affecting entirely at least two lobes), and respiratory failure (pO2/FiO2 <300).
Exclusion criteria
Exclusion criteria: Exclusion criteria included: 1. Age 75 years 2. No written informed consent available 3. Known hypersensitivity to steroids 4. Steroid treatment in the previous 48 hours 5. Need of steroid treatment for any reason (asthma, chronic obstructive pulmonary disease [COPD] etc.) 6. Uncontrolled diabetes mellitus 7. Active peptic ulcer 8. Active Mycobacterial or fungal infection 9. Reported severe imunosuppresion 10. Hospital admission during the previous 8 days 11. Empyema 12. Extrapulmonary septic manifestations 13. Presence of shock 14. Need of mechanical ventilation prior to the inclusion into the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of respiratory failure needing conventional mechanical ventilation (MV) or non-invasive positive pressure ventilation (NNPV), was selected as primary outcome of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Eventual differences in relation to other main variables relative to the outcome, such as days in hospital, need and duration of intensive care unit (ICU) stay and mortality 2. Differences in the inflammatory response measured in venous blood | — |
Countries
Spain
Outcome results
None listed