Hip fracture Musculoskeletal Diseases
Conditions
Interventions
WHiTE 16-DELPHIC is a randomised comparison appended to the World Hip Trauma Evaluation (WHiTE ) Platform. WHiTE is a platform trial designed to efficiently deliver multiple randomised comparisons of
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: As per the overarching Platform Master Protocol; all adults aged 60 years or over diagnosed with a hip fracture that in the opinion of the treating surgeon may benefit from surgical treatment.
Exclusion criteria
Exclusion criteria: Platform exclusion criteria: 1. Previous participation in the same randomised comparison 2. A second hip fracture (on the other side), while the patient is still enrolled in the Platform following their first hip fracture Additional exclusion criteria for DELPHIC: 1. Acute uncontrolled infection as diagnosed by the treating clinician. 2. Hypersensitivity to dexamethasone or excipients within the preparation 3. Use of oral or / intravenous corticosteroids at or following admission. 4. Concurrent participation in a conflicting clinical trial of an investigational medicinal product 5. Receipt of a live vaccine within 2 weeks prior to treatment 6. Known gastrointestinal ulcer 7. Congestive cardiac failure 8. History of steroid psychosis 9. Current glaucoma or corneal ulcer 10. Severe ulcerative colitis 11. Active diverticulitis 12. Suspected or confirmed strongyloidiasis 13. Known history of tuberculosis
Countries
United Kingdom
Contacts
Public ContactMatthew Costa
Outcome results
None listed