Randomised controlled trial of remote ischaemic pre-conditioning to reduce dialysis induced myocardial stunning in haemodialysis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN22392984

Enrollment

Registered

2011-06-21

Start date

2011-05-16

Completion date

Unknown

Last updated

2017-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular, Renal and Urogenital Circulatory System Cardiovascular disease

Interventions

1. Remote pre-conditioning 2. 3 cycles of cuff inflations to 200mmHg for 5 mins 3. Follow Up Length: 1 month

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients having haemodialysis treatment at least 3 times per week at the Royal Derby Hospital 2. Male or female 3. Lower Age Limit 16 years

Exclusion criteria

Exclusion criteria: 1. Not meeting inclusion criteria 2. Exposure to haemodialysis for <90 days prior to recruitment 3. Severe heart failure (New York Heart Association grade IV) 4. Cardiac transplant recipients 5. Mental incapacity to consent 6. Declined to participate 7. Taking cyclosporin 8. Taking ATP-sensitive potassium channel opening or blocking drugs

Design outcomes

Primary

Measure	Time frame
1. Regional wall motion abnormalities on 2D-echo 2. Timepoint(s): Within 4 hours of the stimulus or sham-stimulus	—

Secondary

Measure	Time frame
1. Change in haemodynamic variables after: 1.1. Intervention visit 1.2. First follow-up visit 1.3. Final visit 2. Frequency of intradialytic hypotension after: 2.1. Intervention visit 2.2. First follow-up visit 2.3. Final visit 3. Regional wall motion abnormalities on 2D-echo after: 3.1. First follow-up visit 3.2. Final visit 4. Troponin-T, Plasma IL-6 and N-Type proBNP after: 4.1. Intervention visit 4.2. First follow-up visit 4.3. Final visit	—

Measure

Time frame

1. Change in haemodynamic variables after: 1.1. Intervention visit 1.2. First follow-up visit 1.3. Final visit 2. Frequency of intradialytic hypotension after: 2.1. Intervention visit 2.2. First follow-up visit 2.3. Final visit 3. Regional wall motion abnormalities on 2D-echo after: 3.1. First follow-up visit 3.2. Final visit 4. Troponin-T, Plasma IL-6 and N-Type proBNP after: 4.1. Intervention visit 4.2. First follow-up visit 4.3. Final visit

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026