Does a bolus of ketamine and magnesium at induction improve postoperative analgesia following elective total abdominal hysterectomy?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN22361928

Enrollment

Registered

2005-10-31

Start date

2005-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain relief post hysterectomy Signs and Symptoms

Interventions

Please note that as of 15/07/10 this trial was never started. Randomised controlled trial of ketamine and magnesium versus placebo at induction of anaesthesia.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Adult patients with benign disease, scheduled for hysterectomy and able to give informed consent.

Exclusion criteria

Exclusion criteria: 1. Midline abdominal incision 2. American Society of Anesthesiologists (ASA) >3 3. Age >75 years 4. Long-term use of opioid mediation 5. History of chronic pain syndromes 6. Patients taking antipsychotic medication 7. Major renal or hepatic dsyfunction 8. Neuromuscular disease 9. Surgery - midline incision

Design outcomes

Primary

Measure	Time frame
To determine if the intervention can reduce the use of morphine postoperatively.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026