Stroke Circulatory System Stroke, not specified as haemorrhage or infarction
Conditions
Interventions
This research project is an observational cohort study to evaluate whether blood purine levels measured using a new finger prick blood test (called SMARTChip Purine assay) may differentiate between st
Sponsors
Northumbria Healthcare NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Trained ambulance personnel (paramedics or technicians) responding to an emergency call will attempt a finger prick reading on patients that fulfil the following criteria: Inclusion criteria: 1. Aged 18 years and over 2. At least responsive to strong stimuli during assessment of conscious level (A, V or P on the AVPU scale) 3. Face Arm Speech Test (FAST) positive or any observed new focal neurological symptoms indicating suspected acute stroke in the ambulance personnel's clinical judgement 4. Persistence of the new stroke-like symptoms during the initial clinical assessment 5. Believed to be within 4 hours of the new stroke-like symptoms at the time of the first clinical assessment 6. Will be transported to a study hospital In order to provide the population to fulfil the objectives of the substudy, trained hospital staff (when available) will attempt a reading on the following subgroup of patients: 1. Had an assay reading attempted by ambulance personnel (whether successful or not) 2. The symptoms resulting in admission are believed to have commenced within 6 hours of the time that the hospital assay can be performed 3. The hospital assay can be performed before intravenous thrombolysis or mechanical thrombectomy if this treatment is indicated
Exclusion criteria
Exclusion criteria: Exclusion criteria for the ambulance finger prick reading are: 1. Hypoglycaemia (capillary glucose < 3.5mmol/l) 2. External signs of significant acute trauma which are likely to need additional treatment (large haematomas, open wounds, limb deformity) 3. Currently receiving chemotherapy or radiotherapy treatment for cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity, specificity, negative and positive predictive values, and area under the Receiving Operating Curve (ROC) calculated using purine readings (SMARTChip Purine assay) and results of reference standard tests. Timepoint(s): tests conducted in the emergency ambulance and on arrival at hospital | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed