Coronary artery disease / surgery / endocrinology Surgery Mechanical complication of coronary artery bypass and valve grafts
Conditions
Interventions
Patients who are having elective coronary surgery for the first time will either be randomised to the patient having on or off pump coronary surgery and will have 10 minute sampling of cortisol from t
Sponsors
University of Bristol (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients having isolated CABG surgery must fulfil all the following criteria: 1. Patient having first time, elective CABG 2. Aged 18 - 80yrs 3. Operation to be carried out using median sternotomy 4. Written informed consent
Exclusion criteria
Exclusion criteria: Participant may not enter the study if any of the following apply: 1. Emergency operation 2. Previous sternotomy 3. Myocardial Infarction within the last month 4. Concomitant procedure with CABG 5. Left ventricular ejection fraction <30% 6. Operation to be carried out by other incision than median sternotomy (e.g. left thoracotomy) 7. Contraindication to ONCABG or OPCABG (eg. calcified aorta, intramuscular LAD, calcified coronaries, small target vessels) 8. Use of exogenous corticosteroids (including inhalers) 9. Past history of adrenal / pitiutary disease 10. Other major co-morbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pattern (pulsatility) of cortisol secretion during the peri-operative period, measured using an automated electrochemoluminescent immunoassay (ECLIA) | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of ACTH and CBG measured at three points - anaesthetic induction, end of operation and at 24 hours post surgery | — |
Countries
United Kingdom
Outcome results
None listed