Fetal oedema/hydrops with a focus on lymphatic related hydrops Pregnancy and Childbirth Conditions involving the integument and temperature regulation of fetus and newborn
Conditions
Interventions
PART 1- RETROSPECTIVE AETIOLOGY Study (AIM 1)
Three years’ worth of retrospective data regarding all pregnancies meeting the inclusion criteria will be gathered from the five collaborating fetal medic
Sponsors
St George’s University Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All cases of fetal hydrops at any gestation (as defined by the abnormal accumulation of fluid in two or more fetal compartments) 2. All cases of single compartment oedema (the abnormal accumulation of fluid within a fetal body cavity, for example, ascites, isolated hydrothoraces, generalised skin oedema) 3. Fetuses with a Nuchal Translucency (NT) >4.5mm at the 12/40 ultrasound scan. 4. Individuals affected by fetal oedema or hydrops in-utero for whom no explanation has been identified
Exclusion criteria
Exclusion criteria: Pregnancies with evidence of Rh or other blood group incompatibility (immune hydrops)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1. Measurement of various indices from an ultrasound examination of affected pregnancy Part 2. Information regarding fetal outcome/ child health and development, via a telephone interview with parents, at one year in children with a specific genotype Part 3. Identification of sequence variants from genomic data sets | — |
Countries
England, United Kingdom
Outcome results
None listed