The effect of dietary rapeseed (canola) versus olive oil supplementation on serum lipids, liver enzymes and postprandial inflammatory responses in adipose tissue in obese men.

Single centre, randomized study to investigate the effect of dietary rapeseed (canola) versus olive oil supplementation on serum lipids, liver enzymes and postprandial inflammatory responses in adipose tissue in obese, but otherwise healthy men.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN22073289

Enrollment

Registered

2014-10-08

Start date

2010-09-01

Completion date

Unknown

Last updated

2015-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Nutritional, Metabolic, Endocrine Obesity

Interventions

Eligible individuals were randomized into two treatments to receive a four week daily supplementation with either 50 g of rapeseed oil or 50 g of olive oil. At the end of the supplementation individua

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Males, age between 18 and 65 years 2. Obesity, BMI between 27-35 kg/m²

Exclusion criteria

Exclusion criteria: 1. Diabetes mellituis 2. Alcohol or drug abuse 3. Any medical treatment that affects glucose metabolism, treatment with corticosteroids, treatment with monoaminooxidase inhibitors 4. Any treatment with anticoagulants or any known diseases that affect blood clotting

Design outcomes

Primary

Measure	Time frame
To assess the influence of a daily nutritional supplementation with either 50 g of rapeseed oil or 50 g of olive oil to an isocaloric diet on body composition, serum lipids, serum liver enzymes and inflammatory gene expression in sub cutaneous adipose tissue. Body composition will be determined using an air-displacement plethysmography system and serum lipids and liver enzymes will be measured using standard techniques in a certified laboratory at the German Institute of Human Nutrition before and four weeks after dietary intervention. Inflammatory gene expression in sub cutaneous adipose tissue will be measured four weeks after dietary intervention using quantitative real time-PCR.	—

Measure

Time frame

To assess the influence of a daily nutritional supplementation with either 50 g of rapeseed oil or 50 g of olive oil to an isocaloric diet on body composition, serum lipids, serum liver enzymes and inflammatory gene expression in sub cutaneous adipose tissue. Body composition will be determined using an air-displacement plethysmography system and serum lipids and liver enzymes will be measured using standard techniques in a certified laboratory at the German Institute of Human Nutrition before and four weeks after dietary intervention. Inflammatory gene expression in sub cutaneous adipose tissue will be measured four weeks after dietary intervention using quantitative real time-PCR.

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Secondary

Measure	Time frame
To assess the influence of a daily nutritional supplementation with either 50 g of rapeseed oil or 50 g of olive oil to an isocaloric diet on plasma n-6 and n-3 PUFA content and plasma n-6/n-3 ratio before and four weeks after dietary intervention. n-6 and n-3 PUFA content will be determined after lipid extraction from plasma using thin layer chromatography and gas chromatography. The plasma n-6/n-3 ratio will be calculated.	—

Measure

Time frame

To assess the influence of a daily nutritional supplementation with either 50 g of rapeseed oil or 50 g of olive oil to an isocaloric diet on plasma n-6 and n-3 PUFA content and plasma n-6/n-3 ratio before and four weeks after dietary intervention. n-6 and n-3 PUFA content will be determined after lipid extraction from plasma using thin layer chromatography and gas chromatography. The plasma n-6/n-3 ratio will be calculated.

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Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026