Cobalamin deficiency in primary care: a placebo-controlled, double-blind, randomized trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN22063938

Enrollment

Registered

2006-02-20

Start date

2004-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cobalamin deficiency Nutritional, Metabolic, Endocrine Cobalamin deficiency

Interventions

Oral vitamin B12 versus placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients suspected of cobalamin deficiency with serum vitamin B12 level between 125 and 200 pmole/l. Patients with serum vitamin B12 level below 125 pmole/l were followed-up openly with oral cobalamin.

Exclusion criteria

Exclusion criteria: Unwillingness to participate

Design outcomes

Primary

Measure	Time frame
Evolution of biological markers (serum vitamin B12 level, serum methymalonic acid and homocystein levels)	—

Secondary

Measure	Time frame
Clinical evolution (hematologic, neurologic, psychiatric)	—

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026