Asymptomatic TB transmission in Indonesia and South Africa Infections and Infestations
Conditions
Interventions
This is a multi-country, cross-sectional study designed to assess household Mtb infection and transmission among asymptomatic (aTB) and symptomatic TB (sTB) cases and their household contacts. Communi
Sponsors
Wellcome Trust
Gates Foundation
Eligibility
Sex/Gender
All
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adolescent/Adult participants for community screening: 1. Age >15 years 2. Residence in the designated study area 3. Residence in a household with children (2-14 years) 2. Child household contacts Aged 2-14 years: 1. Household residence with an adolescent/adult participant with: 1.1. aTB-C, or 1.2. sTB-C, or 1.3. An adolescent/adult participant who has been selected as a healthy control (no TB) Adolescent/adult participant in TB screening: 1. Screening W4SS negative 2. Screening sputum Xpert positive (any grade) OR Mtb MGIT positive* OR tongue swab NAAT positive Participants with sTB-C: 1. Adolescent/adult participant in TB screening 2. Screening W4SS positive 3. Screening sputum Xpert positive (any grade) OR Mtb MGIT positive* OR tongue swab NAAT positive Participants selected as healthy controls: 1. Adolescent/adult participant in TB screening 2. Screening W4SS negative 3. Screening sputum Xpert negative; AND Mtb MGIT negative* 4. Selected as a healthy control in the Cross-sectional study of Mtb infection in households (see above) 1. Adolescent/adult participant in TB screening 2. All three sputa Xpert are negative/ ‘trace’ AND all three sputum are Mtb MGIT negative 3. Screening dCXR/CAD interpretation is “suggestive of TB” 4. Clinical assessment at phenotyping visit does not suggest a non-TB aetiology for dCXR/CAD findings and is consistent with TB-U 5. Participant did not commence TB treatment after phenotyping visit
Exclusion criteria
Exclusion criteria: Adolescent/Adult participants for community screening: 1. Unable or unwilling to consent (>18 years) 2. Unable to unwilling to assent (15-17 years) 3. Parent or guardian unwilling to consent (15-17 years) 4. Residence in a household with a participant in a TB vaccine trial (currently or previous 2 years) Child household contacts: 1. Unable or unwilling to assent (>7 years) 2. Parent/guardian unable or unwilling to consent 3. Residence in household in which any resident has been diagnosed with TB within the past 2 years 4. Residence in a household with more than one adolescent/adult with current co-prevalent TB-C 1. Participants with aTB-C ; 2. Participants with sTB-C ; 3. Participants selected as healthy controls ALL 3 groups above: 1. Unable or unwilling to consent * MGIT results returning after enrolment may result in study group re-categorisation 2. Participants who meet the study case definition for bacteriologically-unconfirmed TB (TB-U) 1. Unable or unwilling to consent to longitudinal follow-up
Countries
Indonesia, South Africa
Contacts
Public ContactNompumelelo Ngobese
Outcome results
None listed