Abdominal aortic aneurysm Circulatory System Aortic aneurysm
Conditions
Interventions
10 mg/kg methylprednisolone or dextrose placebo in equal volume given before ischaemia and subsequent reperfusion
Sponsors
Leeds General Infirmary (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Patients presenting to the Vascular Unit for elective abdominal aortic aneurysm repair will be invited to take part. Patients will be aged between 18 and 75.
Exclusion criteria
Exclusion criteria: Patients will be free to withdraw from the study at any time without having to give any reason and without prejudice to clinical care. 1. Diabetic patients 2. Active proven infection 3. Already on steroids 4. Systemic fungal infection 5. Acute renal failure 6. On renal replacement therapy 7. Pregnant or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary N-acetyl-beta-D-glucosaminidase (Beta-NAG) levels over the first post operative week (at baseline, 1 hour, 2, 6, 24 and 48 hours post cross clamp release). | — |
Secondary
| Measure | Time frame |
|---|---|
| Urinary albumin and alpha-1 microglobulin levels over the first post operative week (at baseline, 1 hour, 2, 6, 24 and 48 hours post cross clamp release). | — |
Countries
United Kingdom
Outcome results
None listed