Microvascular Imaging During Abdominal Surgery (MIDAS)

Does intra-operative goal directed fluid therapy (GDT) alter microvascular circulation and reduce clinically important post-operative complications in patients undergoing elective major abdominal surgery?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN21597243

Enrollment

220

Registered

2012-07-26

Start date

2011-03-03

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthetics Surgery

Interventions

Goal directed fluid therapy, supplementary gelatin colloid boluses delivered by investigator according to algorithm based on stroke volume variablity and stroke volume as shown by LiDCO rapid

Follow Up Length: 3 month(s)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients having Rectal Resections or cystectomy 2. Male & female participants 3. Lower age limit = 18 years

Exclusion criteria

Exclusion criteria: Absolute: Unwillingness to participate Inability to perform the tests and consent within the timetable for elective surgery Withdrawn by anaesthetist or surgeon Requirement by the attending anaesthetist to use cardiac output monitoring based on clinical need Acute myocardial infarction (3-5 days) Unstable angina Uncontrolled arrhythmias causing symptoms or haemodynamic compromise Syncope Active endocarditis Acute myocarditis or pericarditis Symptomatic severe aortic stenosis Uncontrolled heart failure Acute pulmonary embolus or pulmonary infarction Thrombosis of lower extremities Suspected dissecting aneurysm Uncontrolled asthma Pulmonary edema Room air desaturation at rest < 85%* Respiratory failure Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis) Relative: Left main coronary stenosis or its equivalent Moderate stenotic valvular heart disease Severe untreated arterial hypertension at rest (200 mm Hg systolic, 120 mm Hg diastolic) Tachyarrhythmias or bradyarrhythmias Highdegree atrioventricular block Hypertrophic cardiomyopathy Significant pulmonary hypertension Advanced or complicated pregnancy Electrolyte abnormalities Orthopaedic impairment that compromises exercise performance

Design outcomes

Primary

Measure	Time frame
Profile of Mood States (POMS) score measured at Day 5	—

Secondary

Measure	Time frame
Microvascular indices measured at baseline, post induction,end operative and on day 1 post operative	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 15, 2026