A trial examining if less fluid administration is better than standard fluid administration in children undergoing kidney transplant

A randomised multiple centre trial of conservative versus liberal fluid administration for children receiving a kidney transplant

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN21516608

Enrollment

140

Registered

2025-07-21

Start date

2025-10-23

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluid management in paediatric kidney transplantation Surgery

Interventions

Summary of treatment in each group: - Intervention: Fluid volume administration capped at maximum 150ml/m²/hour for no longer than 18 hours following transplant, reduced to a fixed daily target of ma

Eligibility

Sex/Gender

All

Age

0 Months to 18 Years

Inclusion criteria

Inclusion criteria: 1. Children under 18 years of age at the time of transplantation with valid informed consent 2. Children receiving a kidney only transplant from either a living or deceased donor, in a participating UK centre

Exclusion criteria

Exclusion criteria: Multi-organ transplant recipients

Design outcomes

Primary

Measure	Time frame
Mean days at home in the first 30 days after kidney transplant measured using patient records	—

Secondary

Measure	Time frame
1. Patient-reported experience of transplant hospital stay (from admission to discharge) 2. Proportion of participants with systemic hypertension (systolic blood pressure above the 95th centile for age and height on 2 consecutive days) within 7 days after transplant 3. Proportion of participants with pulmonary oedema on chest x-ray within 7 days after transplant 4. Proportion of participants with severe acute hyponatraemia (plasma sodium concentration <130mmol/l) within 7 days after transplant 5. Proportion of participants receiving a red blood cells within 7 days after transplant 6. Proportion of participants with transplant thrombosis in the post-operative period leading to graft failure within the first 30 days 7. Proportion of participants with delayed transplant function (dialysis within the first 7 days after transplant) 8. Mean transplant function measured by estimated glomerular filtration rate at 3 months post-transplant 9. Cost-effectiveness analysis: kidney-related costs within the study period (all costs incurred and implications for patient health within the study.)	—

Measure

Time frame

1. Patient-reported experience of transplant hospital stay (from admission to discharge) 2. Proportion of participants with systemic hypertension (systolic blood pressure above the 95th centile for age and height on 2 consecutive days) within 7 days after transplant 3. Proportion of participants with pulmonary oedema on chest x-ray within 7 days after transplant 4. Proportion of participants with severe acute hyponatraemia (plasma sodium concentration <130mmol/l) within 7 days after transplant 5. Proportion of participants receiving a red blood cells within 7 days after transplant 6. Proportion of participants with transplant thrombosis in the post-operative period leading to graft failure within the first 30 days 7. Proportion of participants with delayed transplant function (dialysis within the first 7 days after transplant) 8. Mean transplant function measured by estimated glomerular filtration rate at 3 months post-transplant 9. Cost-effectiveness analysis: kidney-related costs within the study period (all costs incurred and implications for patient health within the study.)

—

Countries

England, Northern Ireland, Scotland, United Kingdom

Contacts

Public ContactFotini Kaloyirou

fotini.kaloyirou@nhsbt.nhs.uk+44 7385388072

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 29, 2026