Breast Cancer Cancer Breast Cancer
Conditions
Interventions
Patients are randomised to receive Intensity Modulated Radiation therapy (IMRT).
Control group will receive standard 2-dimensional radiation therapy.
Sponsors
Cambridge University Hospitals NHS Foundation Trust (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Age 18 years and above 2. Operable unilateral breast cancer (T1-3, N0-1, M0 at presentation) 3. Histological confirmation of invasive carcinoma 4. Complete macroscopic excision of tumour by breast conserving surgery 5. No history of contralateral breast cancer 6. Demonstration of off-axis dose inhomogeneities outside -5% and +7% of the prescribed dose using conventional 2-dimensional radiotherapy treatment plan 7. Patients? consents to be part of the trial and availability for follow-up
Exclusion criteria
Exclusion criteria: 1. Patients with advance or metastatic breast cancer 2. Patients who have had a mastectomy 3. Patients with bilateral breast cancer 4. Concomitant invasive malignancy (apart from Cervical Intra-epithelial Neoplasia [CIN] III uterine cervix and basal carcinoma of the skin), if other previous malignancies, must be disease-free for five years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Breast shrinkage following radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Acute skin reactions 2. Clinical assessment of late cosmetic effect 3. Patient?s quality of life | — |
Countries
United Kingdom
Outcome results
None listed