A randomised controlled trial of triclosan coated sutures in primary total hip and total knee arthroplasty

A randomised controlled trial of Polyglactin 910 Triclosan coated sutures versus standard Polyglactin 910 sutures in patients undergoing primary unilateral hip and knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN21430045

Enrollment

420

Registered

2013-08-20

Start date

2013-08-15

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary total hip and knee replacement patients Surgery

Interventions

Participants will be randomly assigned to receive coated polyglactin 910 sutures with triclosan (Vicryl Plus

Ethicon, Inc.) or conventional sutures (coated polyglactin 910 ¨C Vicryl

Ethicon, Inc.).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients undergoing unilateral primary total hip or knee replacement

Exclusion criteria

Exclusion criteria: 1. Undergoing unilateral primary total hip or knee replacement for trauma 2. Undergoing a revision procedure or with a previous incision in the operative field 3. History of tendency for keloid formation 4. Allergy to triclosan/vicryl 5. Bleeding tendency (e.g. haemophilia and platelet disorders) or on regular anticoagulation treatment (e.g. warfarin, treatment dose of low molecular weight heparin (LMWH) or conventional heparin) 6. Underlying malignancy and immunocompromised status 7. Dementia and mental illnesses preventing informed consent 8. Children (age <18 years)

Design outcomes

Secondary

Measure	Time frame
Secondary objectives include recording data pertaining to demographics, procedure type, length of operating time, plus patient factors believed to influence wound healing and infection risk. Complications associated with using both sutures and their influence on early discharge will also be noted, as this may result in improved patient outcomes, cost effectiveness and long term prosthesis survival.	—

Measure

Time frame

Secondary objectives include recording data pertaining to demographics, procedure type, length of operating time, plus patient factors believed to influence wound healing and infection risk. Complications associated with using both sutures and their influence on early discharge will also be noted, as this may result in improved patient outcomes, cost effectiveness and long term prosthesis survival.

—

Primary

Measure	Time frame
Healing characteristics, using the ASEPSIS wound scoring method devised in 1986 by Wilson et al at University College London Hospitals	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026