Colon, Rectum Cancer Colorectal
Conditions
Interventions
1. Regimen A: Continuous infusion of 5-fluorouracil over 12 weeks.
2. Regimen B: Folinic acid intravenous bolus injection, followed by 5-fluorouracil intravenous bolus injection given on 5 consecutiv
Sponsors
The Royal Marsden NHS Foundation Trust (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Histologically verified adenocarcinoma of colon or rectum, Dukes stages B or C 2. No evidence of residual local disease or metastatic disease as assessed at time of operation, clinical examination, and by ultrasound scanning 3. No past history of malignancy apart from non melanotic carcinoma of the skin or in-situ carcinoma of the cervix 4. No previous chemotherapy 5. Normal bone marrow, renal and liver function 6. Patients must be randomised within 10 weeks of surgery 7. No medical contraindications to treatment
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed